University of California, Riverside

Department of Bioengineering

BIEN Ph.D. Student Donavan A. Argueta featured on UCR Today

BIEN Ph.D. Student Donavan A. Argueta featured on UCR Today

January 23, 2017

UCR Today featured Nicholas DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, and bioengineering Ph.D. student Donavan A. Argueta’s publication Physiology & Behavior. Their publication discusses how western diet leads many to overeating and obesity due to elevations in “peripheral endocannabinoid signaling” through the use of a mouse model. Mice fed on “western diet consumed significantly more calories at a much higher intake” (“UCR Today”).

“These hyperphagic responses to western diet were met with greatly elevated levels of endocannabinoids in the small intestine and circulation,” DiPatrizio said. “Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet-induced obese mice to levels found in control lean mice fed standard chow.”

DiPatrizio and Argueta caution that further research is necessary to identify whether similar mechanisms drive obesity in humans.

To read more about the research, click here.

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University of California, Riverside
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Riverside, CA 92521
Tel: (951) 827-1012

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Department of Bioengineering
205 Materials Science & Engineering

Hours: 8:00 AM - 5:00 PM
Tel: (951) 827-4303
Fax: (951) 827-6416

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